So long as individuals have hearts, there will be those with fears as well as issues. Those hearts are then attacked by something weird, triggering them to reveal unusual physical signs and symptoms. These conditions, called "mystical diseases," exist unseen to many people. Modern medication supplies no cure, however there is one doctor that battles these illness along with his pupils. His name is Ramune. He looks absolutely nothing like a doctor, is foul-mouthed, and also does whatever he pleases, but he has the capability to determine the source of the problems concealed deep within his patients' hearts and cure their mysterious conditions.