As Emily battles to fit in the house as well as at institution, she finds a small red pup who is predestined to become her best friend. When Clifford amazingly undertakes one hell of a development surge, comes to be a gigantic pet and also attracts the attention of a genetics firm, Emily as well as her Uncle Casey have to fight the forces of greed as they take place the run across New York City. Along the way, Clifford affects the lives of every person around him and instructs Emily as well as her uncle the true meaning of approval as well as unconditional love.